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Center for Rare Disease Therapeutic Technology

Center for Rare Disease Therapeutic Technology
Director
  • NameHeeyoung Cho
  • 전화+82-42-860-7426
  • 메일hycho@krict.re.kr
Heeyoung Cho

Major research fields

Establishment of RNA/autophagy modulation low-molecular weight compound platform for the treatment of rare genetic diseases

  • Development of tailor-made low-molecular weight compound convergence platform for the treatment of rare genetic diseases
  • Discovery of high-efficiency rare genetic disease target modulators using virtual screening technology
  • Establishment of cell and animal models to verify efficacy of rare genetic disease targets
  • Ribotac/ASO (antisense oligonucleotide) based chemical modification technology
  • RNA/autophage modulating low-molecular weight compounds development

Next-generation disease model/ and efficacy/drugability evaluation platform, and highly efficient drug efficacy evaluation

  • 3D-biomodel-based rare brain disease efficacy/drugability evaluation system
    • Stem cell/patient-derived organoids and tissue chip-based drugability evaluation models
    • Zebrafish-based efficacy/drugability evaluation system
    • Non-destructive organoid monitoring technology
    • Comparative study of drugability evaluation models alternative to animal testing
  • Biological disease model-based research to create effective materials